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Therapeutic indications

1) Treatment of falciparum (malignant tertian) malaria.

2) Treatment and prevention of nocturnal leg cramps in adults and the elderly, when cramps cause regular disruption of sleep.

Posology and method of administration


For the treatment of falciparum (malignant tertian) malaria:

Adults (including elderly) and children aged 12 years and over: 600mg every eight hours for 7 days. The dose may depend upon the size of the patient, severity of infection, and evidence of renal or liver disease (when the intervals should be increased), due to a prolonged half-life of the drug.

If quinine resistance is known or suspected on completion of the course additional treatment may be given. This may be one of the following:

1. doxycycline 200mg daily (as a single dose or in 2 divided doses) for at least 7 days.

2. clindamycin 300mg four times daily for 5 days.

Children aged 10-12 years: 10mg/kg every eight hours for 7 days.

Children under 10 years: Not recommended

For the treatment and prevention of nocturnal leg cramps:

Adults (including elderly):

The recommended dose is 200mg at bedtime. The maximum dose is 300mg.

A reduction in frequency of leg cramps may take up to 4 weeks to become apparent. Patients should be monitored closely during the early stages of treatment for adverse effects. After an initial trial of 4 weeks, treatment should be stopped if there is no benefit. Treatment should be interrupted at approximately three monthly intervals to assess the need for continuation of treatment with quinine.

Method of Administration

For oral administration.

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